Melanoma diagnosis need both HMB-45 and S100 but S100 is always positive in melanoma.
HMB-45 is specific
S100 is sensitive, so if S100 (-) definitely not melanoma
EIN = endometrial intraepithelial neoplasia
endometrioid adenocarcinoma type I vs. type II
- type I
PTEN positive, early while p1K3CA late gene expression
microsatellite instability
- type II
p53
p16
E-cadherin
myometrial invasion
cytoreduction = debulking surgery (of tumor)
