Wednesday, August 20, 2008

Mucormycosis in a pt with diabetic ketoacidosis

Mucormycosis (zygomycosis)

http://www.som.tulane.edu/classware/pathology/medical_pathology/New_for_98/PulmonaryPath/WithText/MucorHi.jpg

http://www.med.cmu.ac.th/dept/pediatrics/06-interest-cases/ic-41/mucor-vessel-arrow.jpg

http://semj.sums.ac.ir/vol8/oct2007/figure%208.JPG

infects
- neutropenic persons
- ketoacidosis diabetics

organisms
- breadmold fungi
- Mucor, Absidia, Rhizopus, Cunninghamella => Phycomycetes

fungus typically spreads through nasal sinus to the orbit and brain,
=> rhinocerebral mucormycosis
cause tissue necrosis and invasion of vessels

3 primary sites of invasion
- nasal sinuses
- lung
- GI

morphology
- nonseptate
- right angle branching (unlike aspergillus with 60 degrees branching)